blood flow

Why 6 Breaths/Minute Improves Heart Health & Quality of Life in Diabetes

Slow breathing is a highly effective yet overlooked therapy for diabetes.

 

It profoundly changed my life with diabetes, leading me to spend the past 5 years trying to understand it and share it with others.

 

I’ve found that it’s not going to fix everything (of course).  It may not even impact your blood sugars.  But, without question, two things it will do are improve your heart health and your quality of life.

 

And it’s available anytime, anywhere (no pre-authorization required). 

 

I think it’s a no-brainer for better health, and I hope this article inspires you to give it a try.

 

 

What is Slow Breathing? (and why was 6 breaths/minute in the title?)

 

Slow breathing is broadly defined as breathing at a rate of less than 10 breaths per minute.  More specifically, it usually refers to breathing at a rate of about 4.5 to 7 breaths per minute.

 

And even more specifically, almost every study on slow breathing and diabetes has used 6 breaths per minute.  And they’ve found some pretty remarkable things.

 

But before we get to that, let’s take a quick look at the breath-heart connection.

 

 

Understanding the Breath-Heart Connection: Respiratory Sinus Arrhythmia and Heart Rate Variability

 

When we inhale, our heart rate increases.  When we exhale, it decreases (if you’d like more details, here’s a blog I wrote for ResBiotic that explains it fully).  This is known as respiratory sinus arrhythmia (RSA).

 

RSA is one of the underlying principles of heart rate variability (HRV).  Generally speaking, HRV is the beat-to-beat time variability of heart rate.  Research shows that higher HRV indicates a more balanced nervous system and better cardiovascular health.  For these reasons, higher HRV is associated with a better quality of life.

 

And it turns out that people with diabetes typically have worse HRV than non-diabetics.  (A negative side-effect of researching diabetes is that it reminds me of everything it adversely affects.  However, it’s also encouraging to find simple tools like breathing that can help (not fix) some of the problems).

 

 

HRV is Reduced in Diabetes

 

A 2018 meta-analysis found that patients with type-2 diabetes had significantly lower HRV than those without it.  Diabetics with chronic complications have even lower HRV

 

The lower HRV observed in people with diabetes is likely related to many negative aspects of the disease, such as chronic stress, inflammation, and increased oxidative stress. 

 

Perhaps unsurprisingly, low HRV is associated with adverse outcomes in diabetes.  For example, people with diabetes and low HRV are at increased risk of coronary heart disease.  Moreover, low HRV is an early marker of cardiac autonomic neuropathy, which can lead to heart disease, the number one cause of mortality in people with diabetes.

 

Sounds depressing, right?

 

 

Enter the Heart-Boosting Power of Slow Breathing

When we breathe slowly at around 6 breaths per minute, we synchronize signals coming from our cardiovascular, respiratory, and autonomic nervous systems. 

When we breathe slowly at around 6 breaths per minute, we synchronize signals coming from our cardiovascular, respiratory, and autonomic nervous systems. 

 

To get a little more technical, we have baroreceptors monitoring blood pressure. They sense the changes in heart rate that accompany each breath.  Then, they send their own signals to the heart. 

 

For example, as blood pressure rises, they tell the heart to slow down.  And as blood pressure falls, they tell the heart to speed up.

 

Here’s the issue: there’s about a 5-second lag for signals.  Thus, they end up getting mingled together with the signals from the breath.  One may be trying to increase heart rate while the other is trying to slow it down.

 

But when we breathe at about 6 breaths per minute, we synchronize these messages.  (To breathe at 6 breaths per minute, we need about a 5-second inhale and 5-second exhale (or 4/6 also works). This matches the time lag from the baroreceptors.)

 

When the signals get synchronized, great things happen.  Each breath amplifies heart rate oscillations, leading to greater HRV.  This also balances the nervous system, making us calm and relaxed.  If we do this regularly, it can significantly improve our quality of life.

 

Let’s break these down into a little more detail and look at 4 positive outcomes we get from slow breathing.

 

 

The 4 Key Benefits of Heart-Breath Synchronization for Diabetes

 

1. Improved Heart Rate Variability

 

This is the most potent effect.  As mentioned, when we breathe slowly, we amplify the heart rate oscillations occurring with each breath.  This increases HRV, a critical problem in diabetes.

 

One study published in Nature found that just 2 minutes of slow breathing at 6 breaths/min could bring the HRV of type-1 diabetics to levels of non-diabetic controls.  (Side note: this was the paper that convinced me to start sharing this information.  Nature is one of the most prestigious journals in the world.  If they’re talking about slow breathing and diabetes, I realized my results weren’t so crazy after all.)

 

A long-term study of people with type 2 diabetes and ischemic heart disease found that one year of slow diaphragmatic breathing significantly increased HRV, and this wasn’t even at precisely 6 breaths per minute. Just slowing down the breath was enough to boost HRV.

 

And better HRV means better cardiovascular health and a longer life.

 

It also means more resiliency to diabetic stressors, but I’ll save that for another blog post.

And better HRV means better cardiovascular health and a longer life.

 

2. Efficiency and Blood Flow

 

When bodily messages come into harmony, it creates efficiency.  Efficiency means your body doesn’t have to work as hard to complete its normal processes.

 

This efficiency also improves blood flow, a fundamental problem in diabetes.  For example, the same 2-minute study mentioned above found that slow breathing also improved arterial function.  Better arteries, more blood flow, and less chance of complications.

 

 

3. Reduced Blood Pressure

 

Slow breathing has consistently been shown to lower blood pressure.  A 2019 meta-analysis found an average systolic blood pressure reduction of about 5 points from slow breathing for about 20 minutes daily.

 

The blood pressure-reducing effects of slow breathing have also been shown in diabetes.  In a study of 65 type-2 diabetics with hypertension, slow breathing significantly reduced systolic and diastolic blood pressure.

 

These results are significant because Johns Hopkins Medical Center reports that people with diabetes are twice as likely to develop hypertension.  It’s also estimated that anywhere from 40 to 80% of diabetics have hypertension.  Moreover, a person with diabetes and hypertension is four times more likely to develop heart disease.  For these reasons, preventing and treating hypertension is a chief concern in people with diabetes.

 

Slow breathing provides one complementary therapy for doing just that.

 

 

4. Less Stress & Anxiety

 

And lastly, we can’t discuss heart problems without discussing stress.  We know when we’re stressed, we have chronic activation of the sympathetic (fight-or-flight) nervous system.  This raises heart rate and blood pressure, adding extra strain on our hearts.

 

Fortunately, slow breathing is one of the fastest and most effective ways to alleviate stress. You’ve probably been told at some point in your life to “just take a deep breath.”  It turns out there’s some solid science for this statement.

 

Slowing down the breath, especially with a longer exhalation, increases activity in the parasympathetic nervous system (rest-and-digest), reducing stress and increasing relaxation. Slow breathing also reduces activity in the amygdala (often referred to as the “fear center”), which also helps reduce stress.

 

 

Slow Breathing is a Superpower for Your Heart

 

To recap, slow breathing at about 6 breaths per minute is excellent for our hearts, especially if you have diabetes.

 

It harmonizes messages being sent from the cardiovascular and autonomic nervous systems.  This leads to a ton of benefits, but here are 4 critical ones for diabetic heart health:

 

  • Improved heart rate variability

  • Increased efficiency and blood flow

  • Lower blood pressure

  • Less stress and anxiety

 

For these reasons, the paper published in Nature concluded:

Slow breathing could be a simple beneficial intervention in diabetes.
— Nature Scientific Reports

 

Simple and beneficial, indeed.

 

 

Start Improving Your Heart Health Today

 

I hope this article motivates you to start a slow breathing practice.

But, if you’d like some more help, you can check out the Breathing for Diabetes Online Course, which covers everything you need to get started.

I hope you’ll check it out, and if you have any questions about slow breathing in general, please email me at nick@thebreathingdiabetic.  I always respond within 5 days (but usually ~2).


Breathing for Diabetes Online workshop

This may be your key to a healthy, more fulfilling life with diabetes.


 


Inner Resources, Better Blood Flow, and How to Focus on a Fuller Life

 
 

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4 Thoughts


1. Here is the Fastest Way to Achieve Well-Being

So what is the fastest way to achieve well-being? It is so close to you that it can easily be overlooked. Your breath.  A rapid and reliable pathway into your nervous system, dedicated to helping you regain your optimal state.

- Emma Seppälä, Ph.D., The Happiness Track

This is beautifully and perfectly said. Nothing to add here 🙏

2. On Sailboats, HRV, and Developing Your Inner Resources

Developing inner resources is like deepening the keel of a sailboat so that you're more able to deal with the worldly winds—gain and loss, pleasure and pain, praise and blame, fame and slander—without getting tipped over into the reactive mode. Or at least you can recover more quickly.

- Rick Hanson, Ph.D., Neurodharma

Although Dr. Hanson is talking about inner resources in general, this is an excellent analogy for why improving HRV via slow deep breathing is so helpful: it’s like deepening the keel of your physiological sailboat.

You will still be hit by life’s storms, but with higher HRV, you’ll remain steadier and recover quicker. We could say, then, that deep breathing = deep keel.

3. Slow Breathing for Better Blood Flow

“When [the small] blood vessels are relaxed, more blood can flow freely through them. When they become constricted, the same amount of blood flows through a narrower space, increasing your blood pressure.

- Inna Khazan, Ph.D., Biofeedback and Mindfulness in Everyday Life

Slow breathing activates the calming parasympathetic nervous system, which relaxes the small blood vessels, lowers blood pressure, and improves blood flow.

This is a vital benefit of slow breathing because better blood flow is necessary for, well, just about everything (especially if you have diabetes).

So if you feel so inspired, give it a shot. Sit and breathe at 5-6 breaths/min for 2 min. Feel for yourself the rapid boost in blood flow to your hands and/or feet.

***

P.S. I’ve had cold hands & feet for as long as I can remember (thanks, diabetes). Although it’s improved considerably, one of my favorite things about slow breathing is the warmth I feel in them during and after my practice.

4. Control, and How to Focus on a Fuller Life

Even if you don't have control over the outcome of the stressful situation, you may be able to exert some control over its impact…You can't always control what you feel or think, but you can control what you do. Focus on living a full life even though you don’t have [fill in your issue]…

- Melanie Greenberg, Ph.D., The Stress-Proof Brain

When nothing seems to work, my blood sugars still go crazy, my insulin sensitivity is off, or I don’t sleep well, I always have the breath. I have something I can control, that gives me control.

It helps me focus on living a fuller life, and I hope it does for you too 🙏

 
 

 
 

1 QUOTE

“When you own your breath, nobody can steal your peace.”

- Unknown

P.S. Like a lot of what I share, this one is a reminder to myself : ) And it’s advice I haven’t been following that well lately (facepalm).

 
 

 
 

1 ANSWER

Category: Blood Flow

Answer: Although hemoglobin is best-known for releasing oxygen, it also releases this gas, which enhances blood flow and helps the oxygen actually get where it is needed most.

(Cue the Jeopardy! music.)

Question: What is nitric oxide?


In good breath,

Nick Heath, T1D, PhD
“Breathing is the compound interest of health & wellness.”

P.S. hoppity hop, hop hop hop

 
 
 

Sign Up For The Breathing 411

Each Monday, I curate and synthesize information from scientific journals, books, articles, and podcasts to share 4 thoughts, 1 quote, and 1 answer (like "Jeopardy!") related to breathing. It’s a fun way to learn something new each week.

 
 

How Modern Science Supports Ancient Yoga, plus Comfort in Breathwalking

 
 

Listen Instead of Reading


 

The way you breathe might affect your insulin sensitivity. And the way you walk definitely affects your ability to withstand discomfort.

Let’s find out how…

 
 

 
 

4 Thoughts


1. Longer Exhalations are Naturally Relaxing

It's helpful to extend your exhalations because the ‘rest and digest’ parasympathetic nervous system handles exhaling while also slowing your heart rate. So, longer exhalations are naturally relaxing.

- Rick Hanson, Ph.D., Neurodharma

Just a friendly reminder that extending the exhalation is one of the fastest ways to naturally relax. That is all : )

***

Related: Longer Exhalations Are an Easy Way to Hack Your Vagus Nerve

Related: BBC: Why slowing your breathing helps you relax

2. How Breathing Might Help with Insulin Sensitivity

These observations demonstrate that hypoxia rapidly regulated the inhibition of the insulin signaling pathway […] During reoxygenation, the ability of insulin to stimulate phosphorylation of insulin receptor and signaling proteins was restored after 45 min.

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

Insulin resistance is a critical factor in diabetes and overall metabolic health. In this paper, we learn that low tissue oxygen (hypoxia) can trigger insulin resistance. Encouragingly, however, reoxygenation restored it.

This is one reason why optimal breathing is so essential for metabolic health, especially for people with diabetes. By practicing slow nasal breathing, we increase our blood and tissue oxygenation. This could potentially maintain, or even restore, insulin sensitivity.

Of course, there is no research showing that slow nasal breathing does this—no one is going to fund that study : ) But, given what we know about slow breathing, tissue oxygenation, and blood flow, it seems reasonable to hypothesize that it would help. I know have certainly noticed a difference.

***

Related: The Lesser-Known Benefits of Nasal Breathing, Designed for Diabetes

3. “Role of respiration in mind-body practices: concepts from contemporary science and traditional yoga texts”

Traditional yoga texts also suggest a solution for the imbalance in prana, through slow, deep breathing. … The beneficial effects of deep breathing are supported by contemporary science.

- Telles et al. (2014), Frontiers in Psychiatry

I’ve shared a quote from this paper before, but if you haven’t read the full thing, it’s well worth it. It describes how modern science supports ancient yogic breathing, for example, how “Conventional physiology has found benefits of deep breathing supporting the importance given to regulating the breath in yoga.

Another interesting idea they mention is that breathing “acts as both a top-down and bottom-up mind-body practice.” It makes perfect sense, but I hadn’t thought about it that way.

Ancient Yogic Wisdom + Modern Science = A Fantastic Read

Enjoy!

4. Finding Comfort in Breathwalking

To take my mind off the discomfort, I settle into a respiratory rhythm. I take one step as I breathe in, then two steps as I breathe out. One step breathing in, two steps breathing out. Over and over, focusing only on the breath.

- Michael Easter, The Comfort Crisis

Easter spent more than a month in a remote region of Alaska. And this book that came out of it is incredible—a perfect blend of science and storytelling.

Of course, this part stood out to me : )

Easter is making a ridiculous walk back to camp with a ton of weight. He naturally settles into his breath, and this gives him comfort and endurance.

As he puts it, “There's science behind this. Brazilian researchers found that people who are able to detach from their emotions during exercise, for example, not thinking about or putting a negative valence on their burning legs and lungs, almost always perform better.

So aside from the mechanics and oxygenation, here’s another way in which breathwalking can be beneficial. It helps you detach from your emotions. As Easter tells us, you’ll “almost always perform better.” Sounds good to me.

***

Related: Breathwalking with Gandhi

 
 

 
 

1 Quote

“He let me see that, because the breath is so unassuming, I had been undervaluing it. I was looking for a complicated path to enlightenment, when this simple one was right before me.”

- Larry Rosenberg, Breath by Breath

 
 

 
 

1 Answer

Category: Hypoxia

Answer: A blood oxygen saturation below approximately this value is considered hypoxic.

(Cue the Jeopardy! music.)

Question: What is 90%?

P.S. Different places give slightly different numbers…sometimes it’s 94%, sometimes 92%.


In good breath,

Nick Heath, T1D, PhD
“Breathing is the compound interest of health & wellness.”

P.S. What if?

 
 
 

Sign Up For The Breathing 411

Each Monday, I curate and synthesize information from scientific journals, books, articles, and podcasts to share 4 thoughts, 1 quote, and 1 answer (like "Jeopardy!") related to breathing. It’s a fun way to learn something new each week.

 
 

How Bruce Lee Sees Methods, Full Lotus, and the Beauty of Red Blood Cells

 
 

Listen Instead of Reading


 

This week, you'll learn how to become a mixed breathing artist, learn a decade-old idea still relevant today, and take a look into Wim Hof’s mirror.

Enjoy!

 
 

 
 

4 Thoughts


1. On Bruce Lee, “Methods,” and Becoming Mixed Breathing Artists

The individual is of first importance, not the system. Remember that man created method and not that method created man, and do not strain yourself in twisting into someone’s preconceived pattern, which unquestionably would be appropriate for him, but not necessarily for you.

- Bruce Lee, Striking Thoughts

I think we can safely say Bruce Lee would be against using any one breathing “method.” He didn’t even believe there were different forms of fighting.

In fact, many consider Lee to be the original Mixed Martial Artist. Let’s follow his lead and become the first Mixed Breathing Artists.

That means we become both methodical and flexible. We focus on science and self-expression. We don’t strain ourselves to fit into a specific method; instead, we use what’s appropriate for a given situation.

Here’s to using the mixed breathing arts to conquer life’s challenges, today.

***

Related Quote:Any technique, however worthy and desirable, becomes a disease when the mind is obsessed with it.” - Bruce Lee

Another:The more complicated and restricted the method, the lesser the opportunity for the expression of one’s original sense of freedom.” - Bruce Lee

2. What Full Lotus Can Teach Us About Breathing

Years after I had mastered the full Lotus, another teacher walked by while I was sitting, tapped on my shoulder, and gestured toward my full Lotus: ‘That is the whole problem for you.’

- Larry Rosenberg, Breath by Breath

This is one of my new favorite stories. Larry Rosenberg had a teacher who thought sitting in full Lotus was essential. So, he practiced diligently and deliberately for 10 years. Finally, he could sit comfortably in it.

Then, a few years later, a different teacher saw him sitting in Lotus and told him, “That is the whole problem for you.” What one teacher said was essential, another said was his problem. His Lotus was perfect; that wasn’t the issue. It was his obvious attachment to it.

The lesson for us is that we cannot attach ourselves to any one approach to breathing (just like Bruce Lee didn’t attach himself to any single martial art).

Of course, we need to be grounded in science-based principles. But remember to be open. The method you’ve perfected might be the one that’s holding you back the most.

3. From NPR: “Just Breathe: Body Has A Built-In Stress Reliever”

The breath isn't something Western medicine should blow off. It's a powerful tool for influencing individual health and well-being. And the best part is all the ingredients are free and literally right under your nose.

- NPR, Just Breathe: Body Has a Built-In Stress Reliever

NPR published this article over a decade ago, but it’s still relevant today. Check it out to learn how we can use slow and fast breathing to stimulate the nervous system, and how slow breathing might change gene expression.

Enjoy the quick read!

4. The Beauty of Red Blood Cells

These experiments revealed a novel activity of the RBC [red blood cell]: the RBC regulates its own principal function—that is, O2 delivery.

- Extrapulmonary Effects of Inhaled Nitric Oxide

There are about 1 billion oxygen molecules on each of the trillions of red blood cells in your body. That’s a lot of oxygen. As the red blood cells circulate, they deliver this oxygen where it is needed most.

And as it turns out, the red blood cells themselves help regulate this process. Specifically, when they sense areas of low oxygen, they release a bioactive form of nitric oxide. This expands the vessels, which allows more blood flow and, ultimately, more oxygen delivery. It’s quite complex, and quite beautiful.

***

Related: Nitric oxide carried by the red blood cells is essential for blood flow regulation and whole-body oxygenation

 
 

 
 

1 Quote

“In this way, the breath is like a mirror that shows you the state you are in.”

- Wim Hof

 
 

 
 

1 Answer

Category: Oxygen in Your Body

Answer: In terms of atoms, oxygen makes up this percent of total body mass.

(Cue the Jeopardy! music.)

Question: What is 65%?


In good breath,

Nick Heath, T1D, PhD
“Breathing is the compound interest of health & wellness.”

P.S. we should do this more often!

 
 
 

Sign Up For The Breathing 411

Each Monday, I curate and synthesize information from scientific journals, books, articles, and podcasts to share 4 thoughts, 1 quote, and 1 answer (like "Jeopardy!") related to breathing. It’s a fun way to learn something new each week.

 
 

How Breathing Makes Everything Possible

 
 

Listen to this post in 5 minutes:


 

Greetings,

Here are four thoughts, one quote, and one answer for this week. Enjoy!

 
 

 
 

4 Thoughts

1. Breathing Makes Everything Possible

That oxygen, life, and lungs all came into our world in relatively close succession is no coincidence.  Only with oxygen and some means of extracting it are all things possible—thinking, moving, eating, speaking, and loving.  Life and the breath are synonymous.

- Michael J. Stephen, MD, Breath Taking

I often feel crazy. The more I learn about breathing, the more I feel like I must be falling for a big trick. It seems as if all of life’s problems come back to the breath. It really just seems too simple to be true.

Then, I read a beautiful quote like this. One that succinctly states just how breathing, quite literally, makes everything possible. And it reminds me that it is, in fact, the opposite: It’s not crazy that all of life’s problems come back to the breath. It would be crazy if they didn’t.

2. Lesser-Known Ways Nose Breathing Helps Diabetes

You probably know how indispensable nose breathing is by now. But there are other lesser-known reasons it is particularly helpful in diabetes.

In this recent article, I examine nasal breathing through the lens of diabetic complications, nasal and systemic nitric oxide, stress, and sleep.

It’s a different perspective, and I hope you learn something new about nose breathing, whether you have diabetes or not.

If you don’t have time to read it, here are a few take-home messages:

  • People with diabetes have reduced blood flow, reduced tissue oxygenation, and less bioavailable nitric oxide.

  • Nasal breathing increases blood flow, improves tissue oxygenation, and might increase an essential form of bioactive nitric oxide.

3. Take a Deep Breath (American Physiological Society)

That’s the wonderful thing about it. There are no side effects. It’s cheap. And everyone has had the experience of taking a single deep breath—you take one, and you feel it; it’s relaxing.

- Jack Feldman, PhD, Distinguished Professor in Neurobiology at UCLA

This one started out slow, but wow, there was so much good information, especially in the last section on “Slow Breathing and the Brain.

Enjoy the excellent read:

Take a Deep Breath: Featured article from the January 2021 issue of The Physiologist Magazine

4. Why Most Breathing Advice for Beginners is Wrong

"Yes, in our hyperachieving, go-getter world, I’m telling you to lower the bar. Not because I don’t want you to achieve great things, but because I know that you need to start small in order to achieve them."

- BJ Fogg, Tiny Habits

Though well-meaning, most advice for starting a breath practice is wrong.

We’re told we need to do twenty minutes in the morning, twenty minutes before bed, and maybe six additional breathing "check-ins" throughout the day. It’s overwhelming just to think about it.

Sure, if your motivation is high, this approach might work. But it also might set you up for failure, instead of setting you up for long-term growth.

To make it stick, behavior change scientists say we need to start small. For example, starting with 1 minute is more valuable than starting with 1 hour.

And ironically, starting small is the only way to go big. As BJ tells us, "Over the last twenty years, I’ve found that the only consistent, sustainable way to grow big is to start small." Conversely, starting big often leads to giving up.

So let’s lower our breathing bars, start small, and create breathing habits that set us, and those we teach, up for lasting success.

Related: Stanford Researcher BJ Fogg on the ‘Tiny Habits’ That Lead to Big Breakthroughs

 
 

 
 

1 Quote

Oxygen is the life force, the source of life’s infinite possibilities.

- Michael J. Stephen, MD, Breath Taking

 
 

 
 

1 Answer

Answer: Over a lifetime, the average nose hair grows this long.

(Cue the Jeopardy! music.)

Question: What is over 6 feet?

This is the same resource as last week, but this is too ridiculous not to share : )


In good breath,
Nick

P.S. The dmv be like…

 
 

The Lesser-Known Benefits of Nasal Breathing, Designed for Diabetes

 

As a person with type 1 diabetes, my experience with nasal breathing has been nothing short of miraculous.  It's been such a simple change, yet its impacts on my energy and blood sugars have been profound. I feel it would be irresponsible not to share it with other people with diabetes.

Luckily, people much brighter than me have become fascinated by the nose too.  Whole books have now been written on the topic.  It has been featured in popular sources such as Outside Magazine and the Cleveland Clinic.  An article published in Frontiers in Human Neuroscience even concluded that “nasal stimulation represents the fundamental link between slow breathing techniques, brain and autonomic activities and psychological/behavioral outputs.”

But after several years of research, I have come to realize that the reasons nose breathing is so helpful for diabetes go far beyond the “obvious ones.” 

Of course, the usual suspects are essential, such as the warming and humidifying of the incoming air and the natural slowing of the breath.  But to fully understand the benefits for diabetes requires a synthesis of research from different fields, such as diabetic complications, the metabolites of nitric oxide, chronic stress, and sleep.

Let’s start with diabetic complications.

Oxidative Stress and Inflammation Reduce Blood Flow

Over time, the oxidative stress and chronic inflammation associated with diabetes can damage blood vessels, resulting in poor circulation

Less blood flow means that less oxygen reaches the cells, tissues, and organs

As a result of this poor circulation (and other complications), people with diabetes have an increased incidence of retinopathy, kidney disease, and foot problems.

Nose breathing—specifically inhaling through the nose—immediately helps with this.  For example, one small study showed that just five minutes of inhaling through the nose and exhaling through the mouth increased tissue oxygenation by 10%.  This increase was due to nitric oxide.

Nitric oxide is continuously produced in the paranasal sinuses.  When you breathe in through your nose, nitric oxide is carried into the lungs, where it opens up the blood vessels and improves blood flow in the lungs.  This results in better gas exchange and better blood oxygenation.

But that’s only the beginning of NO’s benefits.

How Nitric Oxide Helps with Blood Flow and Oxygenation

Typically, the nitric oxide produced in your nose is treated separately from the nitric oxide produced throughout the rest of your body.  Although it is known that that inhaling nitric oxide has effects outside of the lungs, scientists have not known how. Researchers at the Cleveland Clinic have recently shed light on the issue.

In a 2019 study, they did something simple yet meaningful.  The researchers had participants inhale extra nitric oxide, and they measured what happened in the blood afterward.  If nitric oxide’s journey ended in the lungs, they wouldn’t see any signs of it in distant blood samples.

The results showed the opposite

They found that inhaling nitric oxide significantly increased circulating levels of a specific form of the molecule, SNO-Hb.  These findings matter because, in a separate study published in PNAS in 2015, a different group of researchers found that SNO-Hb played an essential role in whole-body oxygenation.  Without it, mice received less blood flow to the heart and even had smaller litter sizes.

Why This is Important to Diabetes

The complications of diabetes also impact nitric oxide.  Sustained high blood sugars alter how hemoglobin stores nitric oxide. 

The end result is that people with diabetes generally have less SNO-Hb

And, as we just learned, SNO-Hb is critical to blood flow and tissue oxygenation. 

So, putting it all together:

  • People with diabetes suffer from poor circulation and insufficient oxygen.

  • Our noses are a source of nitric oxide—breathing through our nose utilizes it.

  • Inhaling nitric oxide increases an essential form of NO called SNO-Hb.

  • SNO-Hb is critical to improving blood flow and increasing whole-body oxygenation.

Therefore, nose breathing could be especially helpful in diabetes by maintaining normal SNO-Hb levels and hence helping improve blood flow and oxygenation throughout the body.*  Mouth breathing would not provide these benefits.

How High Blood Sugars Reduce Oxygen Delivery

In addition to altering how nitric oxide is stored, high blood sugar also modifies the relationship between oxygen and hemoglobin.  Specifically, it tightens the bond between them.

As a result, less oxygen can be delivered to the places it is needed.  (For the breathing nerds out there, it causes a left shift in the oxyhemoglobin dissociation curve.)  This problem might be further exacerbated by stress.

Chronic Stress and Carbon Dioxide Alter Oxygen Availability

Diabetes also causes chronic stress—a less intense but sustained fight or flight stress response.  This stress causes people with diabetes to have anywhere from 14% to 20% more cases of anxiety than those without it.  Moreover, it has been reported that up to 40% of the diabetic population show symptoms of anxiety.  A 2013 meta-analysis, including over 12,000 people with diabetes, also found significant associations between diabetes and an increased probability of anxiety disorder or anxiety symptoms.

Chronic stress and anxiety, such as that experienced in diabetes, are often associated with overbreathing.  Overbreathing, or hyperventilation, simply refers to breathing more than your metabolic demands at any given moment, and is often associated with mouth breathing. Consequently, the body gets rid of too much carbon dioxide, which alters the pH of the blood.

This has a similar effect on oxygen and hemoglobin as high blood sugar. 

That is, it tightens the bond between them, reducing the amount of oxygen that can be delivered to the cells and tissues (this is known as the Bohr effect).

Together, we see that the high blood sugar and chronic stress associated with diabetes combine to reduce oxygen availability to the cells and tissues.

When we switch to nose breathing, the volume of each breath is naturally reduced.  This helps normalize carbon dioxide levels and restore blood pH to normal levels, which will improve oxygen delivery.** 

Combining this with the earlier discussion on nitric oxide, we see how this one simple change (nose breathing) helps offset some diabetic complications.

Nose Breathing, Sleep, and Diabetes: The Missing Link to Better Blood Sugar Control

If we breathe nasally during sleep, all of the benefits of nose breathing continue throughout the night. Of all the things nose breathing helps with, this might be the most critical for diabetes.

We have already discussed that diabetes causes chronic stress, which can lead to more rapid breathing.  Nose breathing helps naturally slow down the breath.  This will help you shift from a stressful sympathetic state to a calming parasympathetic state.  This shift is significant for people with diabetes who exhibit less parasympathetic tone at night than non-diabetics.  Thus, nasal breathing at night helps us increase parasympathetic tone and enjoy better sleep.

Receptors in your nose also act to maintain rhythmic breathing during sleep.  This might help explain why nose breathing reduces the risk of obstructive sleep apnea when compared to mouth breathing.  Diabetes is associated with a significantly increased risk of obstructive sleep apnea. So, if nasal breathing at night can help reduce this risk, it could be especially beneficial.

Lastly, we know that inadequate sleep causes insulin resistance.  By getting deeper, more restorative sleep, insulin sensitivity can be improved.  This could potentially lead to better morning blood sugars (that was my experience), setting you up for a better day of glucose control.

The More Subjective but Most Important Benefit of Nasal Breathing for Diabetes

Altogether, nasal breathing increases blood flow, improves tissue oxygenation, and appears to increase an essential form of bioactive nitric oxide that people with diabetes have less of.  It also improves sleep quality by helping us flip to a more calming state and by reducing the incidence of sleep apnea.  This can help improve insulin sensitivity.

When we combine all of these together, nasal breathing's net benefit can be simply stated as:

It gives you more energy. 

And it’s harder to objectively measure, but perhaps the best aspect of increased energy levels is more motivation to take care of your blood sugars. 

Diabetes is an exhausting full-time job that can lead to physical and emotional burnout.  Having more energy and enthusiasm to manage the disease could be the most valuable aspect of something as simple as breathing through your nose.

Footnotes:

*The levels of NO inhaled in the 2019 Cleveland Clinic study were greater than those produced in the nose.  But, the study validated that there is a mechanism by which NO that is introduced into the lungs can be transported throughout the body as SNO-Hb.  Thus, nasal breathing would only act to bring SNO-Hb up to normal physiological levels, whereas mouth breathing would rob the body of this important physiological process.

**This discussion is centered around the regular blood sugar fluctuations associated with diabetes and not diabetic ketoacidosis.

 
 

Become A World-Class Breather

 

Greetings,

Here are four thoughts, one quote, and one answer to start off February. Enjoy!

 
 

 
 

4 THOUGHTS

1. Become a World-Class Breather

"World-class performers are less about complexity and more about optimizing simplicity…It’s about the fundamentals. But small, daily improvements on the fundamentals every day done with ridiculous consistency creates insane revolutions over time."

- Robin Sharma, Optimize Interview

Becoming a world-class breather is actually quite simple: reduce the complexity, optimize the simplicity.

Of course, you can still utilize a variety of advanced techniques. Kobe Bryant didn’t only practice shooting free throws, and Tom Brady doesn’t only practice taking snaps. But it all starts with optimizing the fundamentals.

The best way to do that? Nose, belly, quiet, slow, repeat. Let those benefits compound into "insane revolutions over time."

P.S. Don’t forget James Clear’s advice: We have to start before we can optimize.

P.P.S. I condensed the quote, but I’ve never heard so many buzzwords stringed together so eloquently and with so much conviction : ) Enjoy listening.

2. What Optimal Breathing Can Do for Diabetes 

Although it’s not a panacea, improving our breathing might be the simplest thing we can do for our overall health. And for diabetes, in particular, optimal breathing has several direct and indirect benefits that are especially useful.

For example, it can improve cardio-autonomic function, reduce stress and anxiety (see next thought), improve blood flow, and improve sleep. These benefits can lead to better insulin sensitivity, more stable blood sugars, and less risk of long-term complications. Not bad for something as simple as breathing.

3. Harvard Business Review: Why Breathing Is So Effective at Reducing Stress

"So what makes breathing so effective? It’s very difficult to talk your way out of strong emotions like stress, anxiety, or anger…But with breathing techniques, it is possible to gain some mastery over your mind."

- Harvard Business Review,
Research: Why Breathing Is So Effective at Reducing Stress

So much goodness in this quick article. It’s a nice complement to last week’s thought on using breathing instead of thinking, and much more. Enjoy!

4. A Breathing Competition?

Compete: from Latin competere,

in its late sense 'strive or contend for (something)'

from com = 'together' + petere = 'aim at, seek'

- Apple Dictionary

So to "compete" literally means to strive for something together. In that case, we can consider this newsletter to be a breathing competition, with all of us striving to become world-class breathers together.

I hope you enjoy this competition as much as I do.

This thought was inspired by this Optimize +1

 
 

 
 

1 QUOTE

"The pattern of your breathing affects the pattern of your performance. When you are under stress, deep breathing helps bring your mind and body back into the present."

– Gary Mack, Mind Gym

 
 

 
 

1 ANSWER

Answer: This is the longest recorded breath-hold that didn’t use pure oxygen inhalation.

(Cue the Jeopardy! music.)

Question: What is 11 min 35 sec?


 
 

Stop Breathing Sugar

 

Happy Monday!

Let’s get right to it. Here are 4 thoughts, 1 quote, and 1 answer for this week.

 
 

 
 

4 THOUGHTS

1. Breathing is so Cliché

"Defense wins championships // The best defense is a good offense.

Birds of a feather flock together // Opposites attract.

You get what you pay for // The best things in life are free"

- Neil Pasricha, The Happiness Equation

For any situation you’re in, you can find a cliché to help you through. And as seen above, clichés are often contradictory. Likewise, breathing clichés are also contradictory, as we saw about a month ago:

Wim Hof tells you to breathe more. // Patrick McKeown tells you to breathe less.

Lung capacity determines longevity. // But you also shouldn’t take big breaths.

Oxygen is your body’s most important energy source. // But the exhale is the most important part of the breath.

For breathing, I suggested that we embrace these contradictions. But from a practical perspective, I like Neil Pasricha’s advice: "Any cliché, quote, or piece of advice that resonates with you only confirms to your mind something you already know."

We’re all different. So if you notice a specific breathing method standing out, it’s probably confirming something you already know to be right for you.

2. Stop Breathing Sugar

"Cutting sugar-sweetened beverages from your diet is the single-biggest thing you can do to improve your health."

- Mark Hyman, Food Fix

Many different diets work for many different people. But they all pretty much agree on one thing: remove processed sugar. And Mark Hyman’s number one recommendation is even more straightforward: "Don’t drink sugar."

Similarly, despite all the inconsistencies in breathing advice, there is one thing we can all agree on: don’t breathe through your mouth. Mouth breathing is like drinking sugar. It’s easy and it feels good, but it is detrimental to your health.

Let’s cut this processed "breathing sugar" from our diets. It may very well be the most important thing we can do for our health.

Thanks (for the millionth time) to Brian Johnson for inspiring this thought.

3. Nitric Oxide Reduces Alveolar Dead Space

"Alveolar dead space…represents alveoli, typically in the apex of the lung in an upright person, that do not receive blood flow"

- Respiratory Physiology, A Clinical Approach, pg. 96

By redistributing blood flow in the lungs, inhaled nasal nitric oxide reduces the alveolar dead space described above. Specifically, it allows more alveoli to receive blood flow, which allows more gas exchange to occur. This is something you won’t find in textbooks because the science is just too new.

This remarkable effect has led some to postulate that nasal nitric oxide is an evolutionary adaptation that helped allow us to walk upright. Pretty neat.

4. Slow Breathing is Better Than Social Media for Sleep

"Slow-paced breathing appears a promising cost-effective technique to improve subjective sleep quality and cardiovascular function during sleep in young healthy individuals."

- Journal of Clinical Medicine (2019)

This study found that 15 minutes of slow breathing (6 breaths/min) before bed led to better subjective sleep quality than 15 minutes of social media use. Slow breathing also led to higher overnight vagal activity.

Although these results might seem like common sense, I thought they were still compelling nonetheless. Here's to putting away our phones and focusing on our breath before bed.

 
 

 
 

1 QUOTE

"The hardest thing in the world is to simplify your life because everything is pulling you to be more and more complex."

- Yvon Chouinard

 
 

 
 

1 ANSWER

Answer: This condition drops 21% two days after we gain an hour moving from Daylight Savings Time to Standard Time.

(Cue the Jeopardy! music.)

Question: What are heart attacks?


In good breath,
Nick

P.S. lmao ok fine.

 
 

Exciting News: A New Breathing Gas Discovered

 

Happy Monday. There was a breakthrough in breathing research over the past few weeks: A new breathing gas has been discovered. I hope the extra hour of sleep you got this weekend will help this exciting news sink in even deeper.

OK, let’s get to it. Here are 4 thoughts, 1 quote, and 1 answer for you to think about as we begin November.

 
 

 
 

4 THOUGHTS

1. A New Breathing Gas Discovered

"Thus, H2S [hydrogen sulfide] produced by CBS surely has a crucial role in maintaining eupneic-pattern respiration."

- Nature, Communications Biology

Hydrogen sulfide. It’s toxic, and it’s what gives rotten eggs their rotten smell. It also helps maintain our breathing.

A study published in Nature: Communications Biology on October 16, 2020, found that a small amount of hydrogen sulfide is critical to maintaining normal breathing. It does this through modification of the neural connections in the region of the brain that controls breathing.

When hydrogen sulfide production was stopped in rats, normal breathing turned to gasping, implying that it is vital to maintaining rhythmic breathing.

From a practical perspective, I’m not sure what this means yet. At a minimum, breathing now appears to be a four-gas system: oxygen, carbon dioxide, nitric oxide, and hydrogen sulfide.

We’ve found ways to breathe to optimize the first three. However, it’s not yet clear if the way we breathe (or do anything else, for that matter) can influence hydrogen sulfide.

In any case, as a fellow breathing nerd, I hope you find this as fascinating and humbling as I did. Here’s to the joy of never-ending learning.

P.S. Here’s a short summary of these findings from ScienceDaily.

2. The Single Most Important Part of the Breath

"Interestingly, Törnberg et al. recently showed that more NO is released from the nasal passages during nasal inhalation compared with exhalation." - Lundberg et al. (2008)

Here is yet another reason why inhaling through your nose might be the single most important part of breathing: nitric oxide (NO) production is much greater during inhalation than exhalation.

Here’s the finding from the paper mentioned above: "There was a marked flow dependency of nasal NO output, with the highest levels observed during inhalation at flows similar to those seen during normal breathing." - Törnberg et al. (2002)

In hindsight, this makes complete sense. NO helps protect our lungs from inhaled pathogens and it redistributes blood flow in the lungs. So, of course our bodies would maximize it on the inhale. But it wasn’t until I read these two papers that it made sense to me.

"The obvious is that which is never seen until someone expresses it simply.” - Kahlil Gibran

3. What Focusing on the Breath Does to Your Brain

"Conversely, it may be possible to reduce fear and anxiety by slowing down our breath." - Greater Good, UC Berkeley

Here is a quick-reading article, packed full of excellent information, from The Greater Good Science Center at UC Berkeley. Anytime you see a headline like "Managing stress: Is it all in the breath?" you know it’s going to be a good read. Enjoy!

4. Sleep Scientists Call for the Elimination of Daylight Saving Time

"It is, therefore, the position of the American Academy of Sleep Medicine that these seasonal time changes should be abolished in favor of a fixed, national, year-round standard time."

- Journal of Clinical Sleep Medicine

I hope you all enjoyed the extra hour of sleep you got this weekend. The world’s leading sleep scientists say your body will function better, and they suggest we keep it this way (Standard Time) forever.

The above article is pretty short. But if you’re interested, here’s an even more concise summary, along with a rather impressive list of organizations that support the permanent change to Standard Time.

Because nasal breathing at night changed my life, I am endlessly fascinated with sleep. So I hope we all enjoy the next few months of better sleep and better optimization of our body's wake-light cycles.

 
 

 
 

1 QUOTE

“A mind that is stretched by a new experience can never go back to its old dimensions.”

- Oliver Wendell Holmes

 
 

 
 

1 ANSWER

Answer: Average walking speed (~2-4 mph) is also around the average speed of this physiological function.

(Cue the Jeopardy music.)

Question: What is blood flow?


In good breath,
Nick

P.S. New life in a new city.

 
 

Nasal Nitric Oxide: Our Body's Answer to Gravity?

 
sanchez_crespo_et_al_2010_framed.png
 

Gravity is pretty awesome. After all, it keeps us here on Earth. And when our bodies are not subject to gravity (say, if you’re an astronaut), some crazy things happen. For example,

  • Astronauts lose 25% of their aerobic capacity in 7-14 days (it usually takes 10 years to lose 10% here on Earth)

  • Bone density can decrease as fast as 5% a month (it’s usually about 1% a year on Earth)

Thus, our bodies are clearly meant to be under the influence of gravity. However, as we became upright mammals walking on two feet, gravity could have posed an issue.

Blood flow in our lungs is influenced by several factors, but one of the largest is gravity. Gravity acts to focus blood toward the base of the lungs.

Interestingly, in humans and other primates, the nasal airways produce a considerable amount of nitric oxide (NO). As we’ve learned before, NO is a potent vasodilator that is critical for whole-body oxygenation.

Maybe the NO produced in the nasal airways is an adaptation to walking upright and helps counter gravity’s effects on blood flow? That was the hypothesis of the study I’m sharing this week.

Nasal Nitric Oxide: Nature’s Answer to Gravity?

(Read Full Summary Here)

This research found that when participants breathed through their noses, blood flow in the lungs became more uniform and gas exchange was increased. Breathing through the mouth did not have these effects.

However, if subjects breathed through their mouths but were given supplemental NO, the blood flow in their lungs looked similar to nasal breathing.

This suggests that NO is responsible for making blood flow more uniform in the lungs.

The authors hypothesize that nasal NO might be an evolutionary adaptation to counter the effects of gravity on lung blood flow, allowing greater and more efficient gas exchange to occur.

We often praise nasal breathing for its warming and humidifying effects. But the more I learn, the more convinced I am that nitric oxide is the real hero.

In good breath,
Nick

P.S. Happy New Years Dance!